• Future oncology · Dec 2017

    Review

    A review of bevacizumab in the treatment of malignant pleural mesothelioma.

    • Solenn Brosseau, Sandra Assoun, Charles Naltet, Christelle Steinmetz, Valérie Gounant, and Gérard Zalcman.
    • Department of Thoracic Oncology & CIC 1425/CLIP2 Paris-Nord, Bichat-Claude Bernard Hospital, APHP, Paris, France.
    • Future Oncol. 2017 Dec 1; 13 (28): 2537-2546.

    AbstractMalignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis. Systemic chemotherapy is the primary treatment modality for the majority of patients. VEGF plays a key mitogen for MPM cells physiopathology. Bevacizumab, a monoclonal anti-VEGF antibody, was a rational approach to be tested in MPM. Based on the results of the Phase III IFCT-0701 mesothelioma avastin cisplatin pemetrexed study, cisplatin-pemetrexed-bevacizumab is now the accepted standard in France. The National Comprehensive Cancer Network guidelines have also included this combination as an option for standard front-line therapy. This review summarized the efficacy and safety data of bevacizumab in the treatment of patients with MPM.

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