• Internal medicine journal · May 2021

    Unfractionated heparin reduces hepcidin levels in critically ill patients.

    • Dimitrios Vagionas, Marianna Politou, Maria Kompoti, Dimitrios-Dorotheos Papadakis, Eirini Kostakou, Danai Theodoulou, Evangelos Kaniaris, Nikoletta Rovina, Antonia Koutsoukou, and Ioannis Vasileiadis.
    • Intensive Care Unit, First Department of Respiratory Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece.
    • Intern Med J. 2021 May 1; 51 (5): 797-801.

    AbstractA strong anti-hepcidin activity has been observed in heparins. Mean hepcidin levels were significantly reduced compared to baseline, following the first day of unfractionated heparin administration in critically patients. Heparin displayed a strong independent negative association with hepcidin. These results may lead to future treatment methods of forms of anaemia characterised by hepcidin excess, common among the critically ill.© 2021 Royal Australasian College of Physicians.

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