• Internal medicine · Nov 2021

    Case Reports

    Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product.

    • Emiko Kashima, Eri Nakano, Yasuyuki Watanabe, Hiroshi Imai, Koji Oka, Shinichi Kageyama, and Isao Tanaka.
    • Department of Hematology, Suzuka Kaisei Hospital, Japan.
    • Intern. Med. 2021 Nov 15; 60 (22): 3609-3614.

    AbstractAcute myeloid leukemia (AML) with BCR-ABL1, also termed Philadelphia chromosome-positive AML (Ph+ AML), is a rare leukemia subtype classified by the World Health Organization in 2016. The characteristics of Ph+ AML have not been fully identified yet. We herein report a patient with Ph+ AML who phenotypically exhibited megakaryoblastic characteristics, FAB:M7 and harbored a subclone expressing BCR-ABL1 gene fusion products. This case suggests that BCR-ABL1 was acquired as a subclone due to a secondary event that might have occurred late during leukemia evolution. Our findings may aid in deciphering the mechanism underlying Ph+ AML development in future studies.

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