• J. Korean Med. Sci. · May 2021

    Antibody Responses One Year after Mild SARS-CoV-2 Infection.

    • Pyoeng Gyun Choe, Kye Hyung Kim, Chang Kyung Kang, Hyeon Jeong Suh, EunKyo Kang, Sun Young Lee, Nam Joong Kim, Jongyoun Yi, Wan Beom Park, and Myoung Don Oh.
    • Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
    • J. Korean Med. Sci. 2021 May 31; 36 (21): e157.

    AbstractUnderstanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.© 2021 The Korean Academy of Medical Sciences.

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