• Lipids Health Dis · Oct 2011

    Review

    Emerging therapeutic strategies to enhance HDL function.

    • Santiago Redondo, José Martínez-González, Concha Urraca, and Teresa Tejerina.
    • Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Spain. santiredondo@hotmail.com
    • Lipids Health Dis. 2011 Oct 10; 10: 175.

    AbstractEpidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL) and cardiovascular disease (CVD). The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT). New insights in HDL biology and RCT have allowed the development of promising agents aimed to increase HDL function and promote atherosclerosis regression. In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD.

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