• Clin. Pharmacol. Ther. · Aug 2011

    A perhaps unexpected role of norepinephrine in actions of MDMA.

    • T F Newton.
    • Baylor College of Medicine, Houston, Texas, USA. tnewton@bcm.edu
    • Clin. Pharmacol. Ther. 2011 Aug 1; 90 (2): 215-6.

    AbstractIn this issue, Hysek and colleagues present new data describing the impact of treatment with reboxetine on the effects produced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in human volunteers. They demonstrate that several effects of MDMA are mediated by reboxetine's actions on norepinephrine (NE) transporters, an unexpected finding. Building on earlier work, their new data provide new insights into the pharmacodynamics of MDMA and other monoamine-releasing agents.

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