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- Anthony Mato, Shekeab Jauhari, and Stephen J Schuster.
- Center for Chronic Lymphocytic Leukemia and Lymphoma Program, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA.
- Am. J. Hematol. 2015 Jul 1; 90 (7): 657-64.
AbstractThe treatment of patients with chronic lymphocytic leukemia (CLL), an indolent B-cell lymphoma is in the midst of a transformation. There are a large number of promising new therapeutic agents and cellular therapies being studied which exhibit remarkable activity, favorable toxicity profiles, convenient administration schedules, and treatment options are rapidly expanding. The recent advances in the management of CLL exemplify the value of translational medicine. This review highlights key aspects of B-cell receptor (BCR) signaling in relation to novel inhibitors of the BCR signaling pathway, currently at various stages of preclinical and clinical development.© 2015 Wiley Periodicals, Inc.
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