• Marie A Hollenhorst, David A Braun, Christopher R Burtner, Iahn Cajigas, Amy C Cunningham-Bussel, Pinar Ö Eser, Christopher S Nabel, Frederick D Tsai, Lachelle D Weeks, Thomas Michel, and Maria A Yialamas.
• M.A. Hollenhorst is clinical instructor, Division of Pathology, Stanford University School of Medicine, Stanford, California; ORCID: https://orcid.org/0000-0002-2237-6645. D.A. Braun is a fellow, Hematology-Oncology, Massachusetts General Hospital Cancer Center and Dana-Farber Cancer Institute, Boston, Massachusetts. C.R. Burtner is assistant professor, Department of Biology, Roger Williams University, Bristol, Rhode Island. I. Cajigas is a sixth-year resident, Department of Neurological Surgery, University of Miami Leonard M. Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida. A.C. Cunningham-Bussel is a fellow, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts. P.Ö. Eser is a research fellow, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. C.S. Nabel is a fellow, Hematology-Oncology, Massachusetts General Hospital Cancer Center and Dana-Farber Cancer Institute, Boston, Massachusetts. F.D. Tsai is a fellow, Hematology-Oncology, Massachusetts General Hospital Cancer Center and Dana-Farber Cancer Institute, Boston, Massachusetts. L.D. Weeks is a fellow, Hematology-Oncology, Massachusetts General Hospital Cancer Center and Dana-Farber Cancer Institute, Boston, Massachusetts. T. Michel is professor of medicine and co-director, Leder Human Biology and Translational Medicine Program, Biological and Biomedical Sciences, Harvard Medical School, as well as senior physician in medicine, Brigham and Women's Hospital, Boston, Massachusetts. M.A. Yialamas is associate program director, Internal Medicine Residency, Brigham and Women's Hospital, and assistant professor of medicine, Harvard Medical School, Boston, Massachusetts.
• Acad Med. 2020 Apr 1; 95 (4): 548-552.

ProblemAs biomedical research and clinical medicine become increasingly complex, physician-scientists and clinically oriented biomedical researchers play important roles in bridging the gap between disciplines. A lack of educational programming that addresses the unique needs of students preparing for careers at the interface of basic science and clinical medicine may contribute to trainee attrition.ApproachThe MD-PhD/LHB Grand Rounds was introduced in 2008 as a trainee-driven collaborative effort of the Harvard/Massachusetts Institute of Technology MD-PhD program at Harvard Medical School (HMS MD-PhD program), Harvard's Leder Human Biology and Translational Medicine (LHB) program, and the Brigham and Women's Hospital (BWH) Internal Medicine Department. Each of the program's approximately 4 sessions per year begins with dinner, followed by a clinical case presentation led by a BWH MD-PhD resident with a master clinician faculty discussant, then a research presentation by an LHB PhD student or an MD-PhD student on a basic science topic related to the clinical case, and time for socialization.OutcomesIn a July 2017 survey of participating students and residents, respondents reported being highly satisfied with the program. Mean satisfaction ratings were 4.3 (SD 0.5) for 12 MD-PhD students, 4.2 (SD 0.7) for 31 LHB students, and 4.4 (SD 0.9) for 5 residents on a 5-point scale (5 = very satisfied). Free-text responses suggested MD-PhD students valued opportunities for active engagement with the resident presenter and faculty discussant. LHB students appreciated the absence of medical jargon in the clinical presentations. Residents' reported reasons for participating included enjoyment of teaching and interaction with students.Next StepsThe Harvard MD-PhD/LHB Grand Rounds can serve as a template for developing similar programs at other institutions. Research is needed to determine whether such grand rounds programs can help fix the leaky pipeline in the training of future physician-scientists and clinically oriented biomedical researchers.

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