• Vaccine · Feb 2011

    Case Reports

    Delayed focal lipoatrophy after AS03-adjuvanted influenza A (H1N1) 2009 vaccine.

    • Emilie Javelle, Benjamin Soulier, Christian Brosset, Solène Lorcy, and Fabrice Simon.
    • Department of Infectious Diseases and Tropical Medicine, Laveran Military Teaching Hospital, Marseille Cedex 13, France.
    • Vaccine. 2011 Feb 1; 29 (6): 1123-5.

    AbstractIntramuscular vaccination may lead to loss of subcutaneous fat resulting in skin depression at the site of injection. We report for the first time a delayed lipoatrophy after with AS03-adjuvanted influenza A (H1N1) 2009 vaccine. Inadequate administration into the adipose tissue may be causative. During next pandemic, education to optimal intramuscular administration and prolonged monitoring of adverse effects could be proposed.Copyright © 2010 Elsevier Ltd. All rights reserved.

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