• C Pazzaglia, I Imbimbo, E Tranchita, C Minganti, D Ricciardi, R Lo Monaco, A Parisi, and L Padua.
• Department of Neurorehabilitation, IRCCS Don Carlo Gnocchi, Milan, Italy.
• Physiotherapy. 2020 Mar 1; 106: 36-42.

ObjectiveTo compare a 6-week virtual reality (VR) rehabilitation programme with a conventional rehabilitation programme in patients with Parkinson's disease.DesignProspective, single-blinded, randomised controlled trial.SettingOutpatients.ParticipantsFifty-one patients with Parkinson's disease were assigned at random to a VR rehabilitation programme or a conventional rehabilitation programme.InterventionsBoth programmes ran for 6 consecutive weeks, with a 40-minute session three times per week.Main Outcome MeasuresThe Balance Berg Scale (BBS) was used to measure balance. Secondary outcome measures were: Dynamic Gait Index (DGI) to evaluate ability to adapt gait to complex walking tasks; Disabilities of the Arm, Shoulder and Hand (DASH) scale to measure performance of the upper limb; and Short Form 36 (SF-36) to evaluate quality of life.ResultsThe VR rehabilitation programme led to an increase in BBS score {45.6 [standard deviation (SD) 7.9] vs 49.2 (SD 8.1), mean difference 3.6, 95% confidence interval (CI) 1.3 to 5.9; P=0.003}, DGI score [18.7 (SD 4.7) vs 20.2 (SD 4.2), mean difference 1.6, 95% CI 0.6 to 2.5; P=0.003] and SF-36 mental composite score [37.7 (SD 11.4) vs 43.5 (SD 9.2), mean difference 5.8, 95% CI 0.4 to 11.3; P=0.037], and a decrease in DASH scale score [29.6 (SD 17.5) vs 21.6 (SD 15.1), mean difference -7.9, 95% CI -13.7 to -2.2; P=0.009]. In contrast, the conventional rehabilitation programme only led to a decrease in DASH scale score [30.3 (SD 18.1) vs 25.1 (SD 15.8), mean difference -5.2, 95% CI -8.8 to -1.5; P=0.007].ConclusionThese findings suggest that rehabilitation is useful in Parkinson's disease, and the VR rehabilitation programme was more effective in determining overall improvement than the conventional rehabilitation programme.Clinical Trial Registration NumberNCT02807740.Copyright © 2019 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

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