• S Yndgaard, L W Andersen, C Andersen, G Petterson, and L Baek.
• Department of Cardiothoracic Anesthesia and Cardiac Surgery, The Heart Center, University of Copenhagen, Rigshospitalet, Denmark.
• J. Cardiothorac. Vasc. Anesth. 2000 Aug 1; 14 (4): 399-401.

ObjectiveTo determine whether the use of modified ultrafiltration during pediatric cardiopulmonary bypass (CPB) diminishes the load of circulating endotoxins.DesignSingle-arm prospective observational study.SettingA university hospital operating room and intensive care unit.ParticipantsTwenty children undergoing CPB for correction of various congenital heart diseases.InterventionsThe amount of endotoxins in plasma was measured during CPB and before and after modified ultrafiltration. The ultrafiltrate was assayed for the presence of endotoxins. Postoperatively, the children were followed with relevant infectious parameters and cultures.Measurements And Main ResultsThe amount of endotoxins increased significantly during the CPB procedure (from a median of 1.3 ng [range, 0 to 13.7 ng] to 24.2 ng [range, 2.1 to 75.9 ng]). After termination of CPB, modified ultrafiltration was shown to lower the amount of circulating endotoxins in blood (from a median of 24.2 ng [range, 2.1 to 75.4 ng] to 9.0 [range, 0.1 to 40.6 ng]). The major bulk of this reduction in endotoxin load was retrieved in the ultrafiltrate (median of 11.9 ng [range, 0 to 12.1 ng]).ConclusionThis study strongly suggests that modified ultrafiltration decreases the amount of circulating endotoxins in children undergoing cardiac surgery.

12 keywords...

hide…