• Stephan Kische, Giuseppe D'Ancona, Liliya Paranskaya, Jochen Schubert, Nicole Arsoy, Karl Heinz Hauenstein, Anthony Alozie, Bojan Jovanovich, Christoph Nienaber, and Hüseyin Ince.
• Medical Faculty, Department of Cardiology at University Hospital Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany.
• Catheter Cardiovasc Interv. 2013 Oct 1; 82 (4): E552-63.

ObjectivesTo summarize our single Institution experience with staged total percutaneous management of aorto-mitral pathology.BackgroundPercutaneous treatment of aortic valve stenosis (AVS) and mitral valve regurgitation (MVR) has been recently proposed for patients at high surgical risk.MethodsData concerning consecutive patients undergoing percutaneous transcatheter AV implantation (TAVI) followed by MV repair with MitraClip® were prospectively collected and analyzed.ResultsFrom January 2010 to February 2012 a total of 254 patients were referred to undergo TAVI in our Institution. Seventeen (6.7%) had preoperative severe MVR that remained unchanged after TAVI. Due to exacerbation of symptoms 12 patients were subsequently submitted to MV repair with the MitraClip® device. Mean age was 79 years (72-86 years), median Ambler score was 30.1 (17.2-42.6) and EuroSCORE 22.3 (10.2-48.6). Procedural success rate was 100%. Postprocedural hospitalization was 7.1 ± 2.7 and 4.6 ± 0.9 days after TAVI and MV repair, respectively. Six months follow-up echocardiography confirms improvement in LV-EF (37.2 ± 9.9 vs. 43.5 ± 10.7, P < 0.0001). No patient presents MVR exceeding grade I(+) or prosthetic aortic insufficiency > I grade and all patients experienced an improvement in functional status.ConclusionsPercutaneous treatment of AVS and MVR is feasible and safe. A tailored approach should be considered to treat firstly the AVS and subsequently the MVR when severe MV dysfunction and symptoms persist. Short-term durability of this combined percutaneous approach seems encouraging and justifies the economical burden to treat patients that have no other option.Copyright © 2013 Wiley Periodicals, Inc.

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