• Hepatology · Jan 2011

    Effects of the infant stool color card screening program on 5-year outcome of biliary atresia in Taiwan.

    • Tien-Hau Lien, Mei-Hwei Chang, Jia-Feng Wu, Huey-Ling Chen, Hung-Chang Lee, An-Chyi Chen, Mao-Meng Tiao, Tzee-Chung Wu, Yao-Jong Yang, Chieh-Chung Lin, Ming-Wei Lai, Hong-Yuan Hsu, Yen-Hsuan Ni, and Taiwan Infant Stool Color Card Study Group.
    • Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
    • Hepatology. 2011 Jan 1; 53 (1): 202-8.

    UnlabelledIn Taiwan, a screening system using an infant stool color card to promote the early diagnosis of biliary atresia (BA) was established in 2002. This study aimed to investigate the 5-year outcome of BA before and after using the screening program. BA patients were divided into three cohorts according to their birth dates. The patients in cohort A (n = 89) were born before the stool card screening program (1990-2000); those in cohort B (n = 28) were screened by the stool card regional screening program (2002-2003); and those in cohort C (n = 74) were screened by the stool card universal screening program (2004-2005). The relative odds ratios were computed using logistic regression to compare the different factors affecting survival time. The rate of age at Kasai operation <60 days was 49.4% and 65.7% in cohorts A and B+C, respectively (P = 0.02). The jaundice-free (total serum bilirubin <2.0 mg/dL) rate 3 months after surgery was 34.8% and 60.8% in cohorts A and B+C, respectively (P < 0.001). The 3-year jaundice-free survival rate with native liver was 31.5% in cohort A and 56.9% in cohort B+C (P < 0.001), whereas the 3-year overall survival rates were 64.0% and 89.2%, respectively (P < 0.001). The 5-year jaundice-free survival rate with native liver was 27.3% in cohort A and 64.3% in cohort B (P < 0.001), and the 5-year overall survival rates were 55.7% and 89.3%, respectively (P < 0.001).ConclusionThe stool color card screening program for BA allows for earlier Kasai operation, which increases the jaundice-free rate at 3 months postsurgery. With higher surgical success rates, the 3- and 5-year outcome of BA patients in Taiwan improves remarkably.Copyright © 2010 American Association for the Study of Liver Diseases.

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