• Hassan Tavassoli and Ali Heidarianpour.
• Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Bu-Ali Sina University, Hamedan, Iran.
• Am. J. Med. Sci. 2021 Nov 1; 362 (5): 496-505.

BackgroundIrisin and betatrophin are involved in insulin resistance. We investigated the effects of aerobic and resistance exercise (AE/RE) and de-training (cessation of the training after the AE/RE) on betatrophin, irisin and some metabolic factors in rats.MethodsWistar rats were assigned into six groups: non-diabetic rats (C), non-diabetic rats that performed AE/RE, diabetic rats (Dia), and diabetic rats that performed AE/RE (Dia+AE and Dia+RE). Diabetes was induced by high-fat diet/streptozotocin model. The rats de-trained for four weeks after the 12-week exercise training. Blood samples were analyzed by enzyme-linked immunosorbent assay (ELISA) method and statistical analyses were performed using repeated measures and 1-way analysis of variance (ANOVA).ResultsThe 12-week ET improved homeostasis model assessment of IR (HOMA-IR), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglycerides (TG) in the trained diabetic groups (p<0.05). ET reduced betatrophin level in the Dia+RE but not in the Dia+AE group. Positive correlations between betatrophin and body weight (r=0.547; p<0.01), and HOMA-IR (r=0.461; p<0.05) but a negative correlation with LDL-C and TC (r=-0.684, r=-0.669; both p<0.01) were observed, whereas no significant correlation was found between betatrophin and HDL-C and TG (r=-0.225, r=-0.360; both p>0.05). Betatrophin was correlated with irisin in the healthy rats but not the diabetic rats (p<0.01).ConclusionsIt seems that RE has greater efficiency than AE in reducing betatrophin level and irisin resistance. However, de-training caused most of the improvements resulting from RE to be lost, but not the improvements resulting from AE.Copyright © 2021. Published by Elsevier Inc.

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