• Davy van de Sande, Michel E van Genderen, Joost Huiskens, Diederik Gommers, and Jasper van Bommel.
• Department of Adult Intensive Care, Erasmus MC University Medical Center, Room Ne-413, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
• Intensive Care Med. 2021 Jul 1; 47 (7): 750760750-760.

PurposeDue to the increasing demand for intensive care unit (ICU) treatment, and to improve quality and efficiency of care, there is a need for adequate and efficient clinical decision-making. The advancement of artificial intelligence (AI) technologies has resulted in the development of prediction models, which might aid clinical decision-making. This systematic review seeks to give a contemporary overview of the current maturity of AI in the ICU, the research methods behind these studies, and the risk of bias in these studies.MethodsA systematic search was conducted in Embase, Medline, Web of Science Core Collection and Cochrane Central Register of Controlled Trials databases to identify eligible studies. Studies using AI to analyze ICU data were considered eligible. Specifically, the study design, study aim, dataset size, level of validation, level of readiness, and the outcomes of clinical trials were extracted. Risk of bias in individual studies was evaluated by the Prediction model Risk Of Bias ASsessment Tool (PROBAST).ResultsOut of 6455 studies identified through literature search, 494 were included. The most common study design was retrospective [476 studies (96.4% of all studies)] followed by prospective observational [8 (1.6%)] and clinical [10 (2%)] trials. 378 (80.9%) retrospective studies were classified as high risk of bias. No studies were identified that reported on the outcome evaluation of an AI model integrated in routine clinical practice.ConclusionThe vast majority of developed ICU-AI models remain within the testing and prototyping environment; only a handful were actually evaluated in clinical practice. A uniform and structured approach can support the development, safe delivery, and implementation of AI to determine clinical benefit in the ICU.

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