• Zhonghua Wei Chang Wai Ke Za Zhi · Jan 2005

    Clinical Trial

    [Clinical study of the effect of methylene blue combined with aprotinin on intraperitoneal adhesion].

    • Tian-sheng Cao, Rui-hua Liu, and Xiao-ming Sun.
    • Department of General Surgery, Huadu District People's Hospital, Guangzhou 510800, China. caotiansheng@vip.sina.com
    • Zhonghua Wei Chang Wai Ke Za Zhi. 2005 Jan 1; 8 (1): 24-5.

    ObjectiveTo study the effect of methylene blue combined with aprotinin on intraperitoneal adhesion.MethodsFrom May 2000 to February 2004, there were 83 patients receiving total or partial colectomy and temporary ileostomy or colostomy, and second anastomosis was performed within 8-12 weeks after the first operation. These patients were divided into four groups and followed by intraperitoneal administration of saline,methylene blue,aprotinin,combined methylene blue and aprotinin respectively during the second operation, then adhesion formation was quantitatively graded.ResultsThe adhesion rate was 15% in combination group, 83% in saline group, 40% in methylene blue group, and 45% in aprotinin group, respectively. The adhesion rate was significantly lower in combination group(P< 0.05).ConclusionsMethylene blue and aprotinin can decrease the incidence of intraperitoneal adhesion significantly. The combination of these two drugs has significant effectiveness in the treatment of intraperitoneal adhesion.

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