• Pediatr. Nephrol. · Nov 2002

    Case Reports

    Continuous venovenous hemodiafiltration in hypernatremic hyperglycemic nonketotic coma.

    • Jen-Jar Lin, Daniel W McKenney, Cathy Price, R Ray Morrison, and William E Novotny.
    • Division of Nephrology, Department of Pediatrics, Brody School of Medicine, East Carolina University, USA. linj@mail.ecu.edu
    • Pediatr. Nephrol. 2002 Nov 1; 17 (11): 969-73.

    AbstractRapid changes in serum sodium concentration can result in adverse neurological outcome. The gradual correction of hypernatremia in the setting of acute renal failure can be difficult to achieve. We describe an obese female teenager who presented with severe hypernatremia, hyperosmolar hyperglycemic nonketotic coma, acute renal failure, and rhabdomyolysis. Her hypernatremia and other serum chemistries were gradually corrected by repeatedly adjusting the dialysate electrolyte composition used during continuous venovenous hemodiafiltration. She had a full recovery of her renal function. She does not have clinical neurological sequelae from hypernatremia during a 1-year follow-up period.

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