• Neuroreport · May 2001

    Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts.

    • C Y Szeto, N L Tang, D T Lee, and A Stadlin.
    • Department of Anatomy, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
    • Neuroreport. 2001 May 8; 12 (6): 1103-6.

    AbstractMu opioid receptor (MOR) has been shown to be associated with alcoholism and opioid dependence. The present study examined the involvement of a polymorphism in A118G in exon 1 and C1031G in intron 2 of the MOR gene in 200 Chinese heroin-dependent and 97 control subjects. Results showed a significant association for both A118G and C1031G polymorphisms and opioid dependence. The G allele is more common in the heroin-dependent group (39.5% and 30.8% for A118G and C1031G polymorphisms, respectively) when compared to the controls (29.4% and 21.1% for A118G and C1031G polymorphisms, respectively). This study suggests that the variant G allele of both A118G and C1031G polymorphisms may contribute to the vulnerability to heroin dependence.

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