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Trends in neurosciences · May 2014
ReviewZebrafish models for translational neuroscience research: from tank to bedside.
- Adam Michael Stewart, Oliver Braubach, Jan Spitsbergen, Robert Gerlai, and Allan V Kalueff.
- ZENEREI Institute and the International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA; Department of Neuroscience, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA.
- Trends Neurosci. 2014 May 1; 37 (5): 264-78.
AbstractThe zebrafish (Danio rerio) is emerging as a new important species for studying mechanisms of brain function and dysfunction. Focusing on selected central nervous system (CNS) disorders (brain cancer, epilepsy, and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience. We further evaluate the contribution of zebrafish to neuroimaging, circuit level, and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, we also summarize recent applications and existing challenges in this field. Finally, we emphasize the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes. Copyright © 2014 Elsevier Ltd. All rights reserved.
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