• Kardiol Pol · Jan 2005

    Randomized Controlled Trial Clinical Trial

    Effect of leukocyte-depleted blood cardioplegia on the early outcome in patients with preserved left ventricular function undergoing surgical revascularisation.

    • Bronisław Czech, Marek Frank, Ewa Kucewicz, Grzegorz Szapiel, Ryszard Jackowski, Alicja Gabrylewska, and Jolanta Busłowska.
    • Department of Cardiac Surgery, Białystok, Poland.
    • Kardiol Pol. 2005 Jan 1; 62 (1): 26-34.

    BackgroundIt has been shown that leukocytes play one of the key roles in the myocardial reperfusion injury.AimTo examine the effects of cardiac protection with leukocyte-depleted blood cardioplegia on the early outcome of patients with preserved left ventricular function who undergo surgical revascularisation.MethodsThe study group consisted of 58 patients with coronary artery disease (CAD) undergoing coronary artery bypass grafting (CABG) who were randomised to receive leukocyte-depleted blood cardioplegia (leukocyte filter Pall BC1B) (group A, n=29) or to receive standard blood cardioplegia (group B, n=29). Peri-operative mortality and morbidity as well as haemodynamical and biochemical parameters were compared between these two groups.ResultsNo early death occurred. There were no statistical differences in clinical data between the groups. Only cardiac index measured 24 hours after declamping of aorta was significantly higher in group A than in group B (3.6+/-0.6 l/min/m(2) vs 2.95+/-0.45 l/min/m(2), p<0.05). Group B showed significant higher release of creatine kinase (CK) 6 and 12 hours, and CK-MB 6, 12, and 24 hours after unclumping the aorta whereas troponin I level was similar in both groups.ConclusionsThe use of leukocyte-depleted blood cardioplegia during elective CABG did not improve the early outcome.

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