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American heart journal · Nov 2008
Clopidogrel use and bleeding after coronary artery bypass graft surgery.
- John Hyung-Jun Kim, L Kristin Newby, Robert M Clare, Linda K Shaw, Andrew J Lodge, Peter K Smith, E Marc Jolicoeur, Sunil V Rao, Richard C Becker, Daniel B Mark, and Christopher B Granger.
- Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
- Am. Heart J. 2008 Nov 1; 156 (5): 886-92.
BackgroundShort-term use of clopidogrel plus aspirin among patients with acute coronary syndrome reduces ischemic events, but concerns about coronary artery bypass graft (CABG) surgery-related bleeding limit its early use.MethodsUsing data from 4,794 consecutive CABG procedures in the Duke Databank for Cardiovascular Disease (January 1999 to December 2003), we developed multivariable models for associations with CABG-related bleeding defined as reoperation for bleeding, red cell transfusion, and a composite of reoperation/transfusion/hematocrit drop>or=15%. We examined clopidogrel use
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