• J. Thorac. Cardiovasc. Surg. · Nov 2014

    Randomized Controlled Trial Comparative Study

    Graft patency after off-pump coronary artery bypass surgery is inferior even with identical heparinization protocols: results from the Danish On-pump Versus Off-pump Randomization Study (DOORS).

    • Kim Houlind, Morten Fenger-Grøn, Susanne J Holme, Bo J Kjeldsen, Susanne N Madsen, Bodil S Rasmussen, Mogens H Jepsen, Jan Ravkilde, Jens Aaroe, Peter Riis Hansen, Henrik Steen Hansen, Poul Erik Mortensen, and DOORS Study Group.
    • Department of Cardiothoracic Surgery, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark; Institute of Regional Heath Services Research, University of Southern Denmark, Odense, Denmark. Electronic address: kim.houlind@iekf.au.dk.
    • J. Thorac. Cardiovasc. Surg.. 2014 Nov 1;148(5):1812-1819.e2.

    ObjectiveTo determine whether graft patency after on-pump and off-pump coronary artery bypass surgery is similar when performed using the same heparinization protocol.MethodsIn a randomized, controlled, multicenter trial, 900 patients more than 70 years of age received either on-pump or off-pump coronary artery bypass surgery. Heparin was given to achieve an activated clotting time of 400 seconds before arteriotomy in both groups. After the procedure, protamine sulfate was given to revert the activated clotting time to less than 120 seconds. Coronary angiography was performed 6 months after the operation and graft patency was assessed by independent blinded observers.ResultsA total of 481 patients underwent angiography. In the off-pump group, 561 (79%) of 710 grafts were open, 65 (9%) were stenotic, and 84 (12%) were occluded. In the on-pump group, 549 (86%) of 650 grafts were open, 38 (5%) were stenotic, and 63 (9%) were occluded. The difference between the proportion of open grafts was statistically significant in favor of on-pump surgery (P=.01). The proportion of open left internal thoracic artery grafts was 95% in both groups. Perioperative use of intracoronary shunts did not increase the risk of stenosis of the coronary artery distal to the anastomosis.ConclusionsDespite comparable heparinization, graft patency after off-pump surgery was inferior to that after on-pump surgery.Copyright © 2014 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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