• Clin. Pharmacol. Ther. · May 2010

    Review

    The Biomarkers Consortium: practice and pitfalls of open-source precompetitive collaboration.

    • J A Wagner, M Prince, E C Wright, M M Ennis, J Kochan, D J R Nunez, B Schneider, M-D Wang, Y Chen, S Ghosh, B J Musser, and M T Vassileva.
    • Merck, Rahway, New Jersey, USA.
    • Clin. Pharmacol. Ther. 2010 May 1; 87 (5): 539-42.

    AbstractPrecompetitive collaboration is a growing driver for innovation and increased productivity in biomedical science and drug development. The Biomarkers Consortium, a public-private platform for precompetitive collaboration specific to biomarkers, demonstrated that adiponectin has potential utility as a predictor of metabolic responses to peroxisome proliferator-activated receptor (PPAR) agonists in individuals with type 2 diabetes. Despite the challenges overcome by this project, the most important lesson learned is that cross-company precompetitive collaboration is a feasible robust approach to biomarker qualification.

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