• S Togo, C Kunisaki, Y Moriwaki, S Yamaguchi, Y Ichikawa, S Oki, H Shimada, M Takahashi, H Ike, T Fukushima, Y Obi, A Kubo, T Takahashi, H Hosoi, S Fukazawa, T Suda, and Y Yamazaki.
• Dept. of Surgery II, Yokohama City University.
• Gan To Kagaku Ryoho. 2000 Jul 1; 27 (7): 1021-8.

AbstractWe investigated the antiemetic effect, safety and usefulness of granisetron hydrochloride tablets on nausea and vomiting induced by oral anticancer drugs used in chemotherapy for gastric cancer and colorectal cancer. In the present trial, oral administration of granisetron hydrochloride was performed during 5 days after nausea or vomiting. 1) Clinically, the effective rate of granisetron hydrochloride (the percentage of cases in which the drug was assessed as "Remarkably effective" or "Effective") was more than 75% on each day of administration. There were no adverse events or abnormal laboratory tests. 2) In terms of usefulness, granisetron hydrochloride was rated "Extremely useful" or "Useful" in 17 out of 23 cases (78.2%). The above results have shown that granisetron hydrochloride tablets, administrated orally once daily at a dose of 2 mg, have an excellent antiemetic effect, and that this is a safe and useful drug.

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