• Edgar Denova-Gutiérrez, Hugo Lopez-Gatell, Jose L Alomia-Zegarra, Ruy López-Ridaura, Christian A Zaragoza-Jimenez, Dwigth D Dyer-Leal, Ricardo Cortés-Alcala, Tania Villa-Reyes, Rosaura Gutiérrez-Vargas, Kathia Rodríguez-González, Carlos Escondrillas-Maya, Tonatiuh Barrientos-Gutiérrez, Juan A Rivera, and Simón Barquera.
• Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
• Obesity (Silver Spring). 2020 Oct 1; 28 (10): 1826-1832.

ObjectiveThis study's aim was to explore the association of obesity, type 2 diabetes, and hypertension with severe coronavirus disease 2019 (COVID-19) on admission.MethodsIn the present study, a total of 23,593 patient samples were evaluated by a laboratory from the Mexican Institute of Epidemiological Diagnosis and Reference. Of these, 18,443 were negative for COVID-19, 3,844 were positive for COVID-19, and 1,306 were positive for other respiratory viruses. Severe types of respiratory disease were defined by the presence of pneumonia and other organ failure that requires intensive care. Multivariable logistic regression models were used to explore factors associated with severe COVID-19 on admission.ResultsPatients who tested positive for COVID-19 had a higher proportion of obesity (17.4%), diabetes (14.5%), and hypertension (18.9%) compared with those without a confirmed diagnosis. Compared with patients without obesity, those with obesity showed a 1.43-fold higher odds of developing severe COVID-19 on admission, whereas subjects with diabetes and hypertension showed a 1.87-fold and 1.77-fold higher odds of developing severe COVID-19 on admission, respectively.ConclusionsObesity, diabetes, and hypertension were significantly associated with severe COVID-19 on admission and the association of obesity was stronger in patients < 50 years of age.© 2020 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).

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