• Allan V Kalueff, Adam Michael Stewart, Michael Nguyen, Cai Song, and Irving I Gottesman.
• Research Institute for Marine Drugs and Nutrition, College for Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong 524025, China; ZENEREI Institute, 309 Palmer Court, Slidell, LA 70458, USA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, 199034, Russia. Electronic address: avkalueff@gmail.com.
• Prog. Neuropsychopharmacol. Biol. Psychiatry. 2015 Dec 3; 63: 76-82.

AbstractOne of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors. Copyright © 2015 Elsevier Inc. All rights reserved.

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