• Antimicrob. Agents Chemother. · Jan 2014

    Activity of ceftolozane-tazobactam against a broad spectrum of recent clinical anaerobic isolates.

    • David R Snydman, Laura A McDermott, and Nilda V Jacobus.
    • Tufts University School of Medicine, Boston, Massachusetts, USA.
    • Antimicrob. Agents Chemother. 2014 Jan 1; 58 (2): 1218-23.

    AbstractWe evaluated in vitro activity of ceftolozane-tazobactam (TOL-TAZ), formerly CXA-201, against recent clinical anaerobic isolates with emphasis on the Bacteroides fragilis group. Ceftolozane-tazobactam showed good activity against B. fragilis species and intermediate to limited activity against other species of Bacteroides. Ceftolozane-tazobactam showed very good activity against Prevotella spp., Fusobacterium spp., and Propionibacterium spp., varying activities against Gram-positive cocci, and limited activity against Clostridium spp.

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