• Interact Cardiovasc Thorac Surg · Mar 2010

    Randomized Controlled Trial Comparative Study

    Clinical performance and biocompatibility of hyaluronan-based heparin-bonded extracorporeal circuits in different risk cohorts.

    • Serdar Gunaydin, Kevin McCusker, Tamer Sari, Mehmet Ali Onur, and Yaman Zorlutuna.
    • University of Kirikkale, Angora Evleri G-8 Bl. No: 1, Ankara, Turkey. sgunaydin@isnet.net.tr
    • Interact Cardiovasc Thorac Surg. 2010 Mar 1; 10 (3): 371-6.

    AbstractThis prospective randomized study compares novel hyaluronan-based heparin-bonded circuits vs. uncoated controls across EuroSCORE patient risk strata including biomaterial evaluation. Over a two-year period, 90 patients undergoing coronary artery bypass grafting were prospectively randomized to one of the two perfusion protocols: Group 1 was treated with hyaluronan-based heparin-bonded preconnected circuits (Vision HFO-GBS, Gish, CA, USA) and Group 2 with identical uncoated controls. Each group was composed of three subgroups (n=15) with respect to preoperative evaluation of low (EuroSCORE 0-2), medium (3-5) and high (6+) risk patients. Blood samples were collected after induction (T1) and heparinization (T2), 15 min after cardiopulmonary bypass start (T3), before cessation of CPB (T4), 15 min after reversal (T5), and the first postoperative day (T6). In high-risk patients, platelet counts demonstrated significant preservation at T4, T5 and leukocyte counts were lower at T5 in hyaluronan group (P

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