• Vien T Truong, Wojciech Mazur, Cassady Palmer, Gregory F Egnaczyk, Dean J Kereiakes, Ian J Sarembock, Joseph K Choo, Satya Shreenivas, Sherif F Nagueh, and Eugene S Chung.
• The Heart and Vascular Center and The Lindner Research Center, The Christ Hospital, Cincinnati, Ohio; The Sue and Bill Butler Research Fellow, The Linder Research Center, Cincinnati, Ohio.
• J Am Soc Echocardiogr. 2019 Sep 1; 32 (9): 1067-1074.e1.

BackgroundLeft ventricular filling pressure (LVFP) has been demonstrated to be a major predictor of poor cardiovascular outcomes. However, estimation of LVFP in patients with aortic stenosis is limited by the high prevalence of significant mitral annular calcification. The aim of this study was to investigate the effect of transcatheter aortic valve replacement on LVFP and the relationship of LVFP to mortality and hospitalization.MethodsThis was a single-center, retrospective study of 140 consecutive patients in sinus rhythm with significant mitral annular calcification who underwent transcatheter aortic valve replacement for severe aortic stenosis from May 2011 to June 2015. Mean follow-up duration was 3.06 ± 1.48 years (minimum, 2.4 years; maximum, 6.5 years). Diastolic function was assessed using recently proposed criteria for those with significant mitral annular calcification. High LVFP was defined as a mitral E/A ratio > 1.8 or a ratio of 0.8 to 1.8 and isovolumic relaxation time < 80 msec.ResultsAt baseline, the proportion of patients with high LVFP was 40.7%, similar to 1 month (39.7%) (P = .86). However, the proportion of patients with high LVFP was significantly decreased at 1 year compared with those at baseline (26.9% vs 40.7%, P = .02). Multivariate analysis showed that high LVFP at baseline significantly increased risk for all-cause mortality compared with patients with normal LVFP (hazard ratio, 2.84; 95% confidence interval, 1.33-6.05; P = .007).ConclusionsHigh baseline LVFP was associated with a significantly increased all-cause mortality, and LVFP does not improve in the short term but only at 1 year after transcatheter aortic valve replacement.Copyright © 2019 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.

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