• Crit Care · May 2021

    Optimising the timing of renal replacement therapy in acute kidney injury.

    • Matthew E Cove, Graeme MacLaren, Daniel Brodie, and John A Kellum.
    • Department of Medicine, National University Singapore, NUHS Tower Block, Level 10, 1E Kent Ridge Road, Singapore, 119228, Singapore. mdcmec@nus.edu.sg.
    • Crit Care. 2021 May 31; 25 (1): 184.

    AbstractThe optimal timing of renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI) has been much debated. Over the past five years several studies have provided new guidance for evidence-based decision-making. High-quality evidence now supports an approach of expectant management in critically ill patients with AKI, where RRT may be deferred up to 72 h unless a life-threatening indication develops. Nevertheless, physicians' judgment still plays a central role in identifying appropriate patients for expectant management.

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