• Paraskevi Vlachou, Dimitris Fagkrezos, Anastasia Tzivelopoulou, Georgia Kyriakopoulou, Petros Maniatis, Charikleia Triantopoulou, and John Papailiou.
• Computed Tomography Department, Konstantopouleio General Hospital, Agias Olgas 3-5, 14233 Nea Ionia, Greece. fdbl@ath.forthnet.gr.
• J Med Case Rep. 2015 Jan 28; 9: 4.

IntroductionSplenic hamartoma is a primary benign tumor of the spleen, which is often found incidentally. Splenic hamartomas are very rare, with approximately 150 cases documented in the literature to date. They represent benign vascular proliferation. Histological findings consist of disorganized stroma and vascular channels of varying width, with or without lymphoid follicles.Case PresentationWe present the case of a 39-year-old Greek woman, with no significant medical history, who was diagnosed incidentally with an enormous splenic hamartoma on computed tomography, finally confirmed by surgery and histopathology. Hamartomas are benign lesions, and it is important to differentiate them from malignancy.ConclusionHamartoma represents a rare vascular entity characterized by a cluster of differentiation 8-positive immunophenotype. It is usually asymptomatic but large hamartomas may present with symptoms such as hemopoetic disorders, which resolve after splenectomy. It is important for radiologists to be able to differentiate splenic hamartoma from malignant entities.

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