• Clinics in chest medicine · Dec 2013

    Review

    Standard nonspecific therapies in the management of pulmonary arterial hypertension.

    • Maor Sauler, Wassim H Fares, and Terence K Trow.
    • Section of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208057, New Haven, CT 06520-8057, USA.
    • Clin. Chest Med. 2013 Dec 1; 34 (4): 799-810.

    AbstractRecent advances in pulmonary arterial hypertension (PAH) research have created a new era of PAH-specific therapies. Although these therapeutics have revolutionized PAH therapy, their innovation was predated by supportive but nonspecific medical therapies adapted from their use in more common cardiopulmonary diseases. These therapies include oxygen therapy, diuretics, digoxin, anticoagulation, and high-dose calcium channel blockers. Expert opinion continues to support the use of adjunct therapies based on current pathologic understandings of PAH combined with some evidence extrapolated from small studies. This article discusses why these therapies continue to play an important role in the treatment of patients with PAH. Copyright © 2013 Elsevier Inc. All rights reserved.

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