• Michele Brignole, Jean-Claude Deharo, Luc De Roy, Carlo Menozzi, Dominique Blommaert, Lara Dabiri, Jean Ruf, and Regis Guieu.
• Department of Cardiology, Arrhythmologic Centre, Ospedali del Tigullio, Lavagna, Italy. mbrignole@ASL4.liguria.it
• J. Am. Coll. Cardiol. 2011 Jul 5; 58 (2): 167-73.

ObjectivesWe present data on patients with syncope due to paroxysmal atrioventricular (AV) block unexplainable in terms of currently known mechanisms.BackgroundParoxysmal AV block is known to be due to intrinsic AV conduction disease or to heightened vagal tone.MethodsWe evaluated 18 patients presenting with unexplained syncope who had: 1) normal baseline standard electrocardiogram (ECG); 2) absence of structural heart disease; and 3) documentation, by means of prolonged ECG monitoring at the time of syncopal relapse, of paroxysmal third-degree AV block with abrupt onset and absence of other rhythm disturbances before or during the block.ResultsThe study group consisted of 9 men and 9 women, mean age 55 ± 19 years, who had recurrent unexplained syncope for 8 ± 7 years and were subsequently followed up for as long as 14 years (4 ± 4 years on average). The patients had no structural heart disease, standard ECG was normal, and electrophysiological study was negative. In all patients, prolonged ECG monitoring documented paroxysmal complete AV block with 1 or multiple consecutive pauses (mean longest pause: 9 ± 7 s at the time of syncope); AV block occurred without P-P cycle lengthening or PR interval prolongation. During the observation time, no patient had permanent AV block; on permanent cardiac pacing, no patient had further syncopal recurrences.ConclusionsCommon clinical and electrophysiological features define a distinct form of syncope due to idiopathic paroxysmal AV block characterized by a long history of recurrent syncope, absence of progression to persistent forms of AV block, and efficacy of cardiac pacing therapy.Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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