• Urol. Clin. North Am. · Feb 2020

    Review

    Identification of Candidates for Salvage Therapy: The Past, Present, and Future of Defining Bacillus Calmette-Guérin Failure.

    • Russell E N Becker, Max R Kates, and Trinity J Bivalacqua.
    • The James Buchanan Brady Urological Institute and Greenberg Bladder Cancer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: rbecker@jhmi.edu.
    • Urol. Clin. North Am. 2020 Feb 1; 47 (1): 15-21.

    AbstractDisease progression and recurrence are common among patients on Bacillus Calmette-Guérin (BCG) therapy, and options for bladder-preserving subsequent therapy remain limited. Ongoing efforts to develop better second-line bladder-sparing therapies rely on clinical trials of patients deemed to have failed management with BCG. This article describes historical definitions of BCG failure, as well as recent efforts to better delineate and refine the clinical criteria for identifying individual patients who will not benefit from further intravesical BCG therapy. It also reviews guidance from the most recent expert consensus panels and professional association guidelines regarding which patients should not receive additional BCG therapy.Copyright © 2019 Elsevier Inc. All rights reserved.

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