-
- Gudrun Würthwein, Barbara Krefeld, Joachim Gerss, and Joachim Boos.
- Zentrum für Klinische Studien, Universitätsklinikum Münster, Germany.
- Onkologie. 2011 Jan 1; 34 (1-2): 16-22.
BackgroundCarboplatin dosing in children is based on renal function and there exists a wealth of formulae available for calculating the body surface area (BSA), the glomerular filtration rate (GFR), and the carboplatin dose.Patients And MethodsA fictitious group of children with different ages and body builds was 'constructed'. For comparison of formulae, bias and precision were assessed.ResultsBSA calculations according to DuBois-DuBois, Gehan-George, Mosteller, and Boyd showed good agreement. GFR calculations according to the weight-based Cole formula and the Léger formula gave comparable results. Regarding GFR in young children, the weight-and creatinine-based Cole and the Schwartz formula showed clear differences. Again, carboplatin dose calculations according to Marina, Newell, and Chatelut are comparable. Moreover, the precision of the creatinine measurement has a clear influence on the result of the dose calculation.ConclusionsThe choice of the GFR formula is more important for the carboplatin dose calculation compared to the BSA or dose equation. GFR calculations in children show marked, age-dependent variations. A sequence of multiple calculation steps (especially for the Schwartz and Marina formulae) may lead to considerable uncertainty and proneness to error in the clinical routine. In high-risk patients, GFR should be measured precisely and complemented by therapeutic drug monitoring.Copyright © 2011 S. Karger AG, Basel.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.