• World J. Gastroenterol. · Jan 2015

    Observational Study

    Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease.

    • Dominika Maciejewska, Arleta Drozd, Piotr Ossowski, Karina Ryterska, Dominika Jamioł-Milc, Marcin Banaszczak, Joanna Raszeja-Wyszomirska, Małgorzata Kaczorowska, Anna Sabinicz, and Ewa Stachowska.
    • Dominika Maciejewska, Arleta Drozd, Piotr Ossowski, Karina Ryterska, Dominika Jamioł-Milc, Marcin Banaszczak, Małgorzata Kaczorowska, Anna Sabinicz, Ewa Stachowska, Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 70-204 Szczecin, Poland.
    • World J. Gastroenterol. 2015 Jan 7; 21 (1): 301-10.

    AimTo investigate whether liver steatosis reduction due to a six-month dietary intervention results in significant changes in the concentrations of fatty acids.MethodsA group of 35 Caucasian individuals diagnosed with different levels of steatosis were prospectively enrolled in the present study. Analysis of the fatty acid profiles was performed according to changes in liver steatosis (liver steatosis reduction by one or two degrees) after a six-month dietary intervention. The diet helped reduce body mass in obese and overweight patients, and stabilize both glycemia and dyslipidemia. Fatty acids were extracted according to the Folch method and analyzed by gas chromatography.ResultsThis study showed significant changes in fatty acid profiles in patients who had reduced liver steatosis by one as well as two degrees. A reduction in liver steatosis by one degree caused a significant increase in the level of the n-3 family: eicosapentaenoic acid (P < 0.055), docosapentaenoic acid-C 22:5 (P < 0.05) and docosahexaenoic acid (P < 0.05). A reduction in liver steatosis by two degrees caused a significant decrease in serum palmitoleic acid-C 16:1 (P < 0.05).ConclusionLiver steatosis reduction is associated with changes in fatty acid profiles, and these changes may reflect an alteration in fatty acid synthesis and metabolism. These findings may help better understand regression of nonalcoholic fatty liver disease.

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