• Aging Us · Aug 2020

    Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19.

    • Chang Li, Jianfang Ye, Qijian Chen, Weihua Hu, Lingling Wang, Yameng Fan, Zhanjin Lu, Jie Chen, Zaishu Chen, Shiyan Chen, Junlu Tong, Wei Xiao, Jin Mei, and Hongyun Lu.
    • Department of Cardiology, Hubei No.3 People's Hospital of Jianghan University, Wuhan 430033, Hubei Province, China.
    • Aging Us. 2020 Aug 14; 12 (15): 15670-15681.

    AbstractEarly identification of severe patients with coronavirus disease 2019 (COVID-19) is very important for individual treatment. We included 203 patients with COVID-19 by propensity score matching in this retrospective, case-control study. The effects of serum lactate dehydrogenase (LDH) at admission on patients with COVID-19 were evaluated. We found that serum LDH levels had a 58.7% sensitivity and 82.0% specificity, based on a best cut-off of 277.00 U/L, for predicting severe COVID-19. And a cut-off of 359.50 U/L of the serum LDH levels resulted in a 93.8% sensitivity, 88.2% specificity for predicting death of COVID-19. Additionally, logistic regression analysis and Cox proportional hazards model respectively indicated that elevated LDH level was an independent risk factor for the severity (HR: 2.73, 95% CI: 1.25-5.97; P=0.012) and mortality (HR: 40.50, 95% CI: 3.65-449.28; P=0.003) of COVID-19. Therefore, elevated LDH level at admission is an independent risk factor for the severity and mortality of COVID-19. LDH can assist in the early evaluating of COVID-19. Clinicians should pay attention to the serum LDH level at admission for patients with COVID-19.

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