• Cell · Jun 2016

    A BH3 Mimetic for Killing Cancer Cells.

    • Douglas R Green.
    • Department of Immunology, St. Jude Children's Research Institute, Memphis, TN 38105, USA. Electronic address: douglas.green@stjude.org.
    • Cell. 2016 Jun 16; 165 (7): 1560.

    AbstractVenetoclax is a BH3 mimetic approved for treating chronic lymphocytic leukemia. Cancer cells are resistant to apoptosis but "primed for death" by elevated BCL-2, which binds to pro-apoptotic proteins and holds them in check. Venetoclax releases this antagonism and is the first approved drug to target a protein-protein interaction. Copyright © 2016. Published by Elsevier Inc.

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