• Asia Pac J Clin Oncol · Oct 2019

    Case Reports

    Osimertinib 160 mg daily for advanced non-small cell lung cancer with leptomeningeal metastasis: A case report.

    • Maverick Wai-Kong Tsang.
    • Hong Kong Adventist Oncology Center, Hong Kong Adventist Hospital, Stubbs Road, Hong Kong.
    • Asia Pac J Clin Oncol. 2019 Oct 1; 15 Suppl 6: 5-7.

    AbstractAdvanced non-small cell lung cancer (NSCLC) with leptomeningeal metastases (LM) is associated with a dismal prognosis of typically 3-9 months. In preclinical and clinical studies, the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor osimertinib has demonstrated activity in the central nervous system (CNS), and studies are ongoing. We report here a case of osimertinib used at 160 mg once daily in a heavily pretreated patient with EGFR exon 20 T790M-negative advanced NSCLC with LM to achieve a partial response, including shrinkage of the LM, for up to 12 months until further progression. The case suggests the feasibility of using osimertinib at a twofold standard dose to treat CNS metastases, irrespective of the T790M mutation status.© 2019 John Wiley & Sons Australia, Ltd.

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