• Pablo Garcia-Manau, Itziar Garcia-Ruiz, Carlota Rodo, Elena Sulleiro, Nerea Maiz, Marina Catalan, Nuria Fernández-Hidalgo, Joan Balcells, Andrés Antón, Elena Carreras, and Anna Suy.
• Maternal Fetal Medicine Unit, Department of Obstetrics, the Microbiology Department, the Pediatric Critical Care Department, and the Department of Infectious Diseases, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, and the Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain.
• Obstet Gynecol. 2020 Nov 1; 136 (5): 1016-1020.

BackgroundThe risk of vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Positive reverse-transcription polymerase chain reaction (RT-PCR) test results for SARS-CoV-2 infection in neonates and placental tissue have been reported, and immunoglobulin M antibodies have been detected in neonates born to mothers with infection.CasesThe first case is a woman at 22 3/7 weeks of gestation with coronavirus disease 2019 (COVID-19) who was admitted to the intensive care unit. In the second case, the patient remained at home with mild symptoms, starting at 20 weeks of gestation. In both cases, fetal skin edema was observed on ultrasound examination while maternal SARS-COV-2 RT-PCR test results were positive and resolved when maternal SARS-COV-2 RT-PCR test results became negative. The RT-PCR test result for SARS-CoV-2 in amniotic fluid was negative in both cases. The two pregnancies are ongoing and uneventful.ConclusionTransient fetal skin edema noted in these two patients with COVID-19 in the second trimester may represent results of fetal infection or altered fetal physiology due to maternal disease or may be unrelated to the maternal illness.

50 keywords...

hide…