• J. Pediatr. Surg. · Jul 2019

    The effects of Kasai procedure on living donor liver transplantation for children with biliary atresia.

    • Shanni Li, Nan Ma, Xingchu Meng, Wei Zhang, Chao Sun, Chong Dong, Kai Wang, Bin Wu, and Wei Gao.
    • Tianjin First Center Hospital, Key Laboratory of Organ Transplant of Tianjin, China.
    • J. Pediatr. Surg. 2019 Jul 1; 54 (7): 1436-1439.

    ObjectiveTo evaluate the effects of Kasai procedure (hepatic portoenterostomy) on living donor liver transplantation (LDLT) for children with biliary atresia (BA).MethodsFrom January 2006 to January 2014, 150 children with BA were treated with LDLT in China. The children were categorized into pre-Kasai and non-Kasai groups, based on whether they had previously undergone Kasai procedure. Clinical data were retrospectively analyzed, and the difference in postoperative survival was compared between the groups. Preoperative data, including height, weight, serum bilirubin, and pediatric end-stage liver disease score, and perioperative blood loss, operation duration, incidence of postoperative surgical complications including vascular complications, bile duct complications, lymphatic fluid leakage, and digestive tract fistula were compared between the groups.ResultsIn total, 89 and 61 children were categorized in the pre-Kasai and non-Kasai groups, respectively. The 1-, 6-, and 12-month survival was 97.8%, 95.4%, and 95.4% for the Kasai group, and 98.4%, 96.7%, and 96.7% for the non-Kasai group, respectively (P > 0.05). The differences in mean operation duration and mean blood loss, and the incidences of outflow tract obstruction, portal vein stenosis, hepatic artery thrombosis, bile duct complications, lymphatic fluid leakage, and digestive tract fistula were not statistically significant between the groups (P > 0.05).ConclusionKasai procedure could effectively delay the requirement of liver transplantation. In light of previous findings that Kasai procedure could significantly improve the liver transplantation-free survival of children with BA, we suggest that Kasai procedure should be used as a first-line treatment method for this condition.Type Of StudyTreatment Study.Level Of EvidenceLevel III.Copyright © 2018 Elsevier Inc. All rights reserved.

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