• J Zhang, Y Chen, X-B Nie, W-H Wu, H Zhang, M Zhang, X-M He, and J-X Lu.
• Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, China.
• Int. J. Tuberc. Lung Dis. 2011 May 1; 15 (5): 594-601.

BackgroundA large number of studies have shown that polymorphisms in the interleukin 10 (IL-10) gene are implicated in susceptibility to tuberculosis (TB). However, the results are inconsistent and inconclusive.ObjectiveA meta-analysis was performed to analyse the association between polymorphisms in the IL-10 gene and TB susceptibility.ResultsA total of 18 studies that referred to three polymorphisms (-1082G/A, -819C/T and -592A/C) were identified. No association was found between these three polymorphisms and TB risk in combined analyses: -1082G/A (AA+AG vs. GG): OR 0.87, 95%CI 0.66-1.14, P = 0.30; -819C/T (TT+TC vs. CC): OR 1.02, 95%CI 0.92-1.14, P = 0.66; -592A/C (CC+CA vs. AA): OR 0.99, 95%CI 0.88-1.11, P = 0.82. However, in the subgroup analysis by ethnicity, European subjects with the -1082(AA+GG) genotypes have a decreased risk of TB: OR 0.55, 95%CI 0.35-0.88, P = 0.01.ConclusionThis meta-analysis suggests that the -1082G/A polymorphism of the IL-10 gene could be a risk factor for TB in Europeans. Further studies with larger populations are required to assess the association between IL-10 polymorphisms and TB susceptibility.

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