• Kareem M Abu-Elmagd, Beverly Kosmach-Park, Guilherme Costa, Mazen Zenati, Lillian Martin, Darlene A Koritsky, Maureen Emerling, Noriko Murase, Geoffrey J Bond, Kyle Soltys, Hiroshi Sogawa, John Lunz, Motaz Al Samman, Nico Shaefer, Rakesh Sindhi, and George V Mazariegos.
• Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. abuelmagdkm@upmc.edu
• Ann. Surg.. 2012 Sep 1;256(3):494-508.

ObjectiveTo assess long-term survival, graft function, and health-related quality of life (QOL) after visceral transplantation.BackgroundDespite continual improvement in early survival, the long-term therapeutic efficacy of visceral transplantation has yet to be defined.MethodsA prospective cross-sectional study was performed on 227 visceral allograft recipients who survived beyond the 5-year milestone. Clinical data were used to assess outcome including graft function and long-term survival predictors. The socioeconomic milestones and QOL measures were assessed by clinical evaluation, professional consultation, and validated QOL inventory.ResultsOf 376 recipients, 227 survived beyond 5 years, with conditional survival of 75% at 10 years and 61% at 15 years. With a mean follow-up of 10 ± 4 years, 177 (92 adults, 85 children) are alive, with 118 (67%) recipients 18 years or older. Nonfunctional social support and noninclusion of the liver in the visceral allograft are the most significant survival risk factors. Nutritional autonomy was achievable in 160 (90%) survivors, with current serum albumin level of 3.7 ± 0.5 gm/dL and body mass index of 25 ± 6 kg/m(2). Despite coexistence or development of neuropsychiatric disorders, most survivors were reintegrated to society with self-sustained socioeconomic status. In parallel, most of the psychological, emotional, and social QOL measures significantly (P < 0.05) improved after transplantation. Current morbidities with potential impact on global health included dysmotility (59%), hypertension (37%), osteoporosis (22%), and diabetes (11%), with significantly (P < 0.05) higher incidence among adult recipients.ConclusionsWith new tactics to further improve long-term survival including social support measures, visceral transplantation has achieved excellent nutritional autonomy and good QOL.

40 keywords...

hide…