• Yoshiaki Kinoshita, Takato Ikeda, Yusuke Ueda, Tomoya Sasaki, Hisako Kushima, and Hiroshi Ishii.
• Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
• Chest. 2021 Jun 1; 159 (6): e389-e394.

Case PresentationA 63-year-old, non-smoking Asian woman presented to our hospital due to abnormal findings on chest radiography. She had no history of dust exposure. Chest radiography and CT imaging showed patchy ground-glass attenuation (GGA) in the bilateral lower lung lobes, a ground-glass nodule in the right lower lung lobe (diameter, 9.8 mm), and some thin-walled cysts in both lungs (Fig 1). Thickening of the interlobular septa, mediastinal lymphadenopathy, and pleural effusion were not evident. Video-assisted thoracic surgery was performed for the examination of the nodule and the background lung disease, and the nodule was histologically diagnosed as lung adenocarcinoma. Simultaneously, the lung background showed diffuse lymphocytic infiltration in the alveolar septum and peribronchovascular interstitium (Fig 2). There were no symptoms suggestive of autoimmune diseases such as dryness, arthralgia, skin rash, or fever. The patient was followed up without treatment for the interstitial lung disease.Copyright © 2021 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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