• Scand J Trauma Resus · Jun 2021

    Standardized post-resuscitation damage assessment of two mechanical chest compression devices: a prospective randomized large animal trial.

    • Robert Ruemmler, Jakob Stein, Bastian Duenges, Miriam Renz, and Erik Kristoffer Hartmann.
    • Department of Anaesthesiology, Medical Centre of the Johannes Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany. Robert.Ruemmler@email.de.
    • Scand J Trauma Resus. 2021 Jun 5; 29 (1): 7979.

    BackgroundMechanical chest compression devices are accepted alternatives for cardiopulmonary resuscitation (CPR) under specific circumstances. Current devices lack prospective and comparative data on their specific cardiovascular effects and potential for severe thoracic injuries.ObjectivesTo compare CPR effectiveness and thoracic injuries of two mechanical chest compression devices in pigs.Study DesignProspective randomised trial.AnimalsEighteen male German landrace pigs.MethodsVentricular fibrillation was induced in anaesthetised and instrumented pigs and the animals were randomised into two intervention groups. Mechanical CPR was initiated by means of LUCAS™ 2 (mCCD1) or Corpuls™ cpr (mCCD2) device. Advanced life support was applied for a maximum of 10 cycles and animals achieving ROSC were monitored for 8 h. Ventilation/perfusion measurements were performed and blood gas analyses were taken. Thoracic injuries were assessed via a standardised damage score.ResultsFive animals of the mCCD1 group and one animal of the mCCD2 group achieved ROSC (p = 0.048). Only the mCCD1 animals survived until the end of the monitoring period (p < 0.01). MCCD1 animals showed less pulmonary shunt (p = 0.025) and higher normal V/Q (p = 0.017) during CPR. MCCD2 animals showed significantly more severe thoracic injuries (p = 0.046).ConclusionThe LUCAS 2 device shows superior resuscitation outcomes and less thoracic injuries compared to Corpuls cpr when used for experimental CPR in juvenile pigs. Researchers should be aware that different mCCDs for experimental studies may significantly influence the respective outcome of resuscitation studies and affect comparability of different trials. Controlled human and animal CPR studies and a standardised post-resuscitation injury evaluation could help to confirm potential hazards.Trial RegistrationTrial approval number: G16-1-042-E4.

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