• Arnaud Tessier, Igor Sibon, Mathilde Poli, Michel Audiffren, Michèle Allard, and Micha Pfeuty.
• Département de psychiatrie adulte, Centre Hospitalier Charles Perrens, CS81285, 33076 Bordeaux Cedex, France; Université de Bordeaux, INCIA, CNRS UMR 5287, F-33000 Bordeaux, France.
• J Stroke Cerebrovasc Dis. 2017 Oct 1; 26 (10): 2435-2441.

BackgroundEarly detection of poststroke depression (PSD) and cognitive impairment (PSCI) remains challenging. It is well documented that the function of autonomic nervous system is associated with depression and cognition. However, their relationship has never been investigated in the early poststroke phase. This pilot study aimed at determining whether resting heart rate (HR) parameters measured in early poststroke phase (1) are associated with early-phase measures of depression and cognition and (2) could be used as new tools for early objective prediction of PSD or PSCI, which could be applicable to patients unable to answer usual questionnaires.MethodsFifty-four patients with first-ever ischemic stroke, without cardiac arrhythmia, were assessed for resting HR and heart rate variability (HRV) within the first week after stroke and for depression and cognition during the first week and at 3 months after stroke.ResultsMultiple regression analyses controlled for age, gender, and stroke severity revealed that higher HR, lower HRV, and higher sympathovagal balance (low-frequency/high-frequency ratio of HRV) were associated with higher severity of depressive symptoms within the first week after stroke. Furthermore, higher sympathovagal balance in early phase predicted higher severity of depressive symptoms at the 3-month follow-up, whereas higher HR and lower HRV in early phase predicted lower global cognitive functioning at the 3-month follow-up.ConclusionsResting HR measurements obtained in early poststroke phase could serve as an objective tool, applicable to patients unable to complete questionnaires, to help in the early prediction of PSD and PSCI.Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

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