• Der Internist · Apr 2018

    Case Reports

    [Hyponatremia in a 58-year-old female patient with EGFR-positive lung adenocarcinoma].

    • M Koch, K Utpatel, and C Schulz.
    • Klinik und Poliklinik für Innere Medizin II (Kardiologie, Pneumologie und Internistische Intensivmedizin), Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland. myriam.koch@klinik.uni-regensburg.de.
    • Internist (Berl). 2018 Apr 1; 59 (4): 384-387.

    AbstractThe case of a 58-year old female patient with epidermal growth factor-positive pulmonary adenocarcinoma treated with the tyrosine kinase inhibitor afatinib is reported. After several months of first-line therapy the patient developed severe hyponatremia and tumor reassessment revealed a progressive course of the lung cancer. Rebiopsy showed transformation of the tumor into small-cell lung cancer. Therapy with afatinib was stopped immediately and platin-based chemotherapy was started. This case shows that tumor transformation under tyrosine kinase inhibitor therapy from non-small-cell into small-cell lung cancer can occur in rare cases.

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