• Journal of cardiology · Aug 2013

    Randomized Controlled Trial

    Effect on periprocedural myocardial infarction of intra-coronary nicorandil prior to percutaneous coronary intervention in stable and unstable angina.

    • Jongmin Hwang, Han Cheol Lee, Bo-Won Kim, Mi Jin Yang, Jin-Sup Park, Jong-Ha Park, Hye-Won Lee, Junhyok Oh, Jung Hyun Choi, Kwang Soo Cha, Taek Jong Hong, Seunghwan Song, and Sang-Pil Kim.
    • Division of Cardiology, Department of Internal Medicine, College of Medicine, Pusan National University, Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
    • J Cardiol. 2013 Aug 1; 62 (2): 77-81.

    BackgroundIntravenous nicorandil infusion dilates the coronary artery and reduces inflammation, coronary spasm, and arrhythmia. Periprocedural myocardial infarction (PMI) is a frequent and prognostically important complication of percutaneous coronary intervention (PCI). This prospective randomized study was designed to evaluate the efficacy of intracoronary nicorandil on PMI after elective PCI.Methods And ResultsEighty-one patients with stable or unstable angina undergoing PCIs of the left anterior descending artery were randomly assigned to the nicorandil group (n=41) or the control group (n=40). In the nicorandil group, 4 mg of intracoronary nicorandil was infused prior to PCI. Post-PCI, peak levels of creatine kinase (CK)-MB and troponin I were measured and angiographic findings were analyzed. Side branch status was also assessed. All PCIs were successful. One cerebrovascular infarction and one acute ST segment elevation myocardial infarction with acute stent thrombosis occurred in the nicorandil group. No deaths occurred, and no other major cardiac adverse events were observed in either group over 6 months follow-up. The post-PCI peak CK-MB and troponin I levels were not significantly different between the two groups. There were no significant differences between the nicorandil and control subjects in side branch occlusion or flow reduction, or in the jail index.ConclusionsIntra-coronary nicorandil infusion had no significant effect on PMI and cardiac enzymes after PCI in patients with stable or unstable angina.Copyright © 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

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