• Francesco Sturla, Francesco Onorati, Emiliano Votta, Konstantinos Pechlivanidis, Marco Stevanella, Aldo D Milano, Giovanni Puppini, Alessandro Mazzucco, Alberto Redaelli, and Giuseppe Faggian.
• Division of Cardiovascular Surgery, Università degli Studi di Verona, Verona, Italy; Department of Electronics, Informatics and Bioengineering, Politecnico di Milano, Milan, Italy. Electronic address: francesco.sturla@univr.it.
• J. Thorac. Cardiovasc. Surg.. 2014 Sep 1;148(3):1025-34; discussion 1034.

ObjectivesFinite element modeling was adopted to quantitatively compare, for the first time and on a patient-specific basis, the biomechanical effects of a broad spectrum of different neochordal implantation techniques for the repair of isolated posterior mitral leaflet prolapse.MethodsCardiac magnetic resonance images were acquired from 4 patients undergoing surgery. A patient-specific 3-dimensional model of the mitral apparatus and the motion of the annulus and papillary muscles were reconstructed. The location and extent of the prolapsing region were confirmed by intraoperative findings, and the mechanical properties of the mitral leaflets, chordae tendineae and expanded polytetrafluoroethylene neochordae were included. Mitral systolic biomechanics was simulated under preoperative conditions and after 5 different neochordal procedures: single neochorda, double neochorda, standard neochordal loop with 3 neochordae of the same length and 2 premeasured loops with 1 common neochordal loop and 3 different branched neochordae arising from it, alternatively one third and two thirds of the entire length.ResultsThe best repair in terms of biomechanics was achieved with a specific neochordal technique in the single patient, according to the location of the prolapsing region. However, all techniques achieved a slight reduction in papillary muscle forces and tension relief in intact native chordae proximal to the prolapsing region. Multiple neochordae implantation improved the repositioning of the prolapsing region below the annular plane and better redistributed mechanical stresses on the leaflet.ConclusionsAlthough applied on a small cohort of patients, systematic biomechanical differences were noticed between neochordal techniques, potentially affecting their short- to long-term clinical outcomes. This study opens the way to patient-specific optimization of neochordal techniques.Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

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