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Neuroscience letters · Apr 1989
Chronic amitriptyline decreases autotomy following dorsal rhizotomy in rats.
- F Abad, M Feria, and J Boada.
- Department of Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
- Neurosci. Lett. 1989 Apr 24; 99 (1-2): 187-90.
AbstractIn the rat, unilateral dorsal cervicothoracic rhizotomy (C5-T1), a proposed model of chronic pain, resulted in autotomy of the ipsilateral limb. The self-mutilation lesions were evaluated daily by means of an autotomy score from the 1st to the 80th postoperatory day. The onset of lesions was variable and attained the maximum degree 8-9 weeks after the dorsal roots section. Chronic administration of amitriptyline (5 and 10 mg/kg/day, i.p., over 30 days), started on the 10th day after rhizotomy, decreased autotomy behavior, an effect which persisted 20 days after treatment withdrawal, and lengthened almost two-fold the lag time between rhizotomy and appearance of lesions. A more pronounced effect was observed with the lowest dose of amitriptyline suggesting the existence of a therapeutic window. Possible mechanisms for the antinociceptive effect of amitriptyline in this model are discussed.
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